Cefoperazone
● Inhibits growth of haemophilus, neisseria species, non-enterococcal streptococci & anaerobic gram +ve cocci.
Sulbactum
● Increases antimicrobial spectrum & clinical effectiveness of cefoperazone against gram -ve bacilli & β-lactamase gram +ve enterobacteriaceae.
Combination
● Highly safe, clinically effective & viable alternative than aminoglycoside & clindamycin for intra-abdominal infection.
● Superior synergistic effect against K.pneumoniae, P.mirabilis & P.vulgaris than cefoperazone alone.