Tramadol
● Centrally acting analgesic agent.
● Enhances inhibitory effects on pain transmission in spinal cord. -Clin Pharmacokinet. 2004;43 Suppl 2:25-33
● Clinically effective analgesic efficacy is 10 times higher than morphine -Drug 1997;53 Suppl 2:25-33
● Well tolerated in post operative pain
Paracetamol
● Enhances the analgesic action of tramadol